  Graham writes … After a number of frustrating delays, the uncrewed, moon orbiting, test mission designated Artemis 1 finally got off the launchpad on 16 November 2022. You may recall that one of these delays was not insignificant, due to the arrival of Hurricane Ian which caused a return of the launch vehicle to the shelter of the Vehicle Assembly Building. The mission lasted about three and half weeks, finally splashing down in the Pacific Ocean on 11 December 2022. The objectives of the mission were achieved, the principal one being to test out the Orion spacecraft systems, prior to the future launch of crewed missions. The mission profile is rather more elaborate than that of the Apollo missions, as illustrated by the accompanying graphic. This blog post is essentially a picture gallery of aspects of the mission. In retrospect, I realised that the beautiful blue orb of the Earth features significantly in my choice of images. Also many of the images are ‘selfies’, showing elements of the spacecraft. This is achieved by using imagers attached to the spacecraft’s solar panels. All images are courtesy of NASA. I hope you enjoy the beauty and grandeur of God's creation in what follow ...!  1. The Artemis 1 Space Launch System on the pad.  2. A close up of the Orion spacecraft in launch configuration, with launch escape tower attached.  3. Spectators watch Artemis 1 as it makes its way to orbit (16 November 2022).  4. Orion’s camera looks back on ‘the good Earth’ as the vehicle makes its way to the moon. The picture is captured by a ‘selfie stick’ installed on one of the solar panels. The image also shows the European service module’s propulsion system, featuring the main orbit transfer engine, the smaller trajectory adjustment thrusters, and, smaller still, the attitude control thrusters. One of the solar panels is prominent.  5. Approaching the moon.  6. Lunar surface detail captured during the close powered swingby.  7. Lunar surface detail captured during the close powered swingby.  8. The Earth and the moon can be seen beyond the conical crew capsule. The large structural collar at its base provides protection for the capsule’s heatshield.  9. Crescent Earth and crescent moon from Orion. A striking and beautiful picture, perhaps reminiscent of an ‘Apollo 13’ film poster!  10. The Earth looms large again as Orion races towards atmospheric re-entry.  11. Parachute landing after a successful re-entry (11 December 2022).  12. Capsule recovery led by USS Portland. So, after the successful flight of Artemis 1, what does the future hold? In contrast to the ‘manic’ flight schedule of the Apollo programme leading up to the first landing in July 1969, the Artemis schedule is frustratingly more relaxed! The next event is the launch of Artemis 2, which is planned for May 2024. This will be the first crewed mission of the Orion system with a planned duration of 10 days. Note that we no longer refer to ‘manned’ missions, as the upcoming flights will involve the participation of lady astronauts! This second flight will take people out to a flyby of the moon, thus giving the system a thorough test with people on board.  An artist's impression of the SpaceX Starship HLS on the lunar surface, planned for 2025. Then, planned for 2025, the Artemis 3 mission will land astronauts on the moon for the first time since Apollo 17 in 1972. To supply the flight infrastructure to transfer astronauts from lunar orbit to the moon’s surface, and back, NASA have contracted the private company SpaceX. In recent times, this enterprise has proved itself in supplying a reliable transfer system, taking astronauts to and from the Earth-orbiting International Space Station. SpaceX proposes using a lunar landing variant of its Starship spacecraft, called the Starship HLS (Human Landing System). See the image above, showing an artist’s impression of the SpaceX HLS on the lunar surface – a monstrous vehicle in comparison to the Apollo era Lunar Excursion Module. There seems to be a lot of questions as to why NASA has chosen this route, but that’s a story for another time!
Graham Swinerd Southampton January 2023
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 Credit: www.protothema.gr John writes … The past few months have seen announcements of several new medical treatments based on manipulating DNA. I want to highlight just a couple of these which illustrate how techniques developed in research labs are helping doctors to use knowledge about genes and genetics to treat conditions which had previously been incurable.  Credit: Goodreads The first concerns haemophilia, a condition in which blood fails to clot. It is caused by the absence of a protein involved in the clotting process which is in turn caused by a mutation in the gene encoding that protein. In 85% of haemophilia cases, it is Factor VIII that is missing. This particular mutation is famous because of its presence in Queen Victoria’s family, as described beautifully in Queen Victoria’s Gene by D.M. and W.T.W. Potts. The remaining 15% of cases involve a different clotting factor, Factor IX, and are again caused by a mutation in the relevant gene. Both conditions are suitable targets for somatic cell gene therapy in which the cells that make the protein – both these factors are made in the liver – are supplied with a functional copy of the gene. But, despite the basic simplicity of that process, achieving it is much more difficult, as my students have often heard me say. Indeed, despite early optimism, treating Factor VIII deficiency via gene therapy has not yet been achieved. However, there has been success in treating the rarer condition, Factor IX deficiency, as reported by the BBC back in the summer: Transformational therapy cures haemophilia B – BBC News. The process is relatively simple. The gene encoding Factor IX is inserted into an engineered harmless adenovirus which can make itself at home in the liver and thus deliver the desired gene to the liver cells. One person, Elliott Mason (pictured below), who has undergone this treatment, which, for the patient, involves a one-hour infusion of the engineered virus into the liver, said that it was astonishing to see that his Factor IX levels had gone from 1% of normal to being in the normal range. He added "I've not had any treatment since I had my therapy, it's all a miracle really, well it's science, but it feels quite miraculous to me." The team of scientists and doctors involved in developing this treatment believes that the patients who received it will not need another gene infusion for at least eight years.  Elliot Mason My second example is successful treatment of T-cell acute lymphoblastic leukaemia which had resisted all other treatments. Earlier this month, doctors at the world-famous Great Ormond Street Hospital in London (www.gosh.nhs.uk) announced a ‘first’ in that they had used DNA base-editing to cure a 13-year-old girl, Alyssa, of her leukaemia: see Base editing: Revolutionary therapy clears girl’s incurable cancer – BBC News. I’ll explain what they did later in this post but for the minute I want to go back seven years. DNA base-editing is a very precise and sophisticated form of genome editing. Genome editing was used in 2015, also at Great Ormond Street, to treat a baby, Layla Richards, with an equally resistant acute lymphoblastic leukaemia. The technique was completely new; it had never been used on a human patient but the local medical ethics committee readily gave permission for its use because without it, the little girl was certain to die. As I have previously described (1), donated T-cells (T-cells are the immune system’s hunters) were subjected to very specific and targeted genetic modification and genome editing to enable them to hunt down and eradicate the cancer cells. The modified T-cells were infused into Layla and within two months she was completely cancer-free. Building on this success, the team used the same technique a few months later to treat another very young leukaemia patient (2). Returning to the present day, the team treating Alyssa again used donated T-cells. These were then modified by DNA base-editing as shown in the diagram below.  As with the earlier treatments, a genetic modification was also required to enable the edited T-cells to bind to and destroy the cancerous T-cells. Alyssa is part of a trial that also includes nine other patients but she is the first for whom results of the treatment are available. She says ‘"You just learn to appreciate every little thing. I'm just so grateful that I'm here now. It's crazy. It's just amazing [that] I've been able to have this opportunity, I'm very thankful for it and it's going to help other children, as well, in the future.”
One of the inventors of DNA base-editing, Dr David Lui, was delighted that the technique had been used in this life-saving way: “It is a bit surreal that people were being treated just six years after the technology was invented. Therapeutic applications of base-editing are just beginning and it is humbling to be part of this era of therapeutic human gene-editing." John Bryant Topsham, Devon. December 2022 (1) Introduction to Bioethics, 2nd edition, John Bryant and Linda la Velle, Wiley, 2018. p139. (2) Two baby girls with leukaemia ‘cured’ using gene-editing therapy – Genetic Literacy Project.  There is a time for everything and a season for every activity under the heavens … (Ecclesiastes 3, v1) He has made everything beautiful in its time. He has also set eternity in the human heart … (Ecclesiastes 3, v11) John writes … I quoted these verses at the front of my PhD thesis many years ago. They sandwich a passage in which ‘[there is] a time to …’ as used in the folk song ‘Turn, turn, turn.’ Many people have some familiarity with at least part of the passage without knowing that it comes from the Bible. The version of ‘Turn, turn, turn’ recorded in 1966 by Pete Seeger was recently played on BBC radio. It was obvious that the programme’s presenter was one of those who do not know that the words are Biblical – he ascribed them to the anti-war movement of the 1960s.  In recent days I have gone back to these verses and again thought about them in relation to the creation. The existence of seasons results from the way our planet is set up but it doesn’t have to be that way. Planets without seasons are perfectly good planets. So, as I enjoy the lovely autumn colours and indeed understand the underlying biology, I thank God that He has made everything beautiful in its time.  But that also challenges me. Autumns are getting warmer; the biological changes, except those driven entirely by day-length, are occurring later. Ecosystems are changing because the climate is changing; this is a matter for prayer and urgent action.  John Bryant
Topsham, Devon November 2022 All pictures are credited to the author.  Graham writes … In October’s post, John discussed the winner of the Nobel Prize of Physiology and Medicine, and this month I’d like to say something about the work of the winners of the Physics Prize, and the extraordinary things it says about the nature of reality. There were three winners, Alain Aspect, John Clauser and Anton Zeilinger, and broadly speaking they earned the prize for their work on the topic of quantum entanglement. So what is quantum entanglement, and why is it important? I’d like to say something about this concept, hopefully in language that is accessible to non-physicists As you may know, prior to the 1900s, the laws devised by Isaac Newton reigned supreme. It is also fair to say that for many engineering and science applications today, Newton’s theory still works. This classical theory is elegant, compact and powerful, and is still part of the education of a young science student today. One of the main aspects of Newton’s physics is what it says about the nature of reality. Put simply, if you tell me how the world is now, then the theory will tell you precisely how the world will be tomorrow (or indeed yesterday). In other words, if the positions and velocity of all the particles in the Universe were known at a particular time, then in principle Newton will be able to determine the state of all the particles at another time. This total determinism is a defining facet of Newtonian physics. However, in the early years of the 20th Century, the comforting edifice of classical physics collapsed under the onslaught of a new theory. Physicists investigating the world of the very small – the realm of molecules, atoms and elementary particles – found that Newton’s laws no longer worked. A huge developmental effort on the part of scientists, such as Einstein, Planck, Bohr, Heisenberg, Schrödinger and others, ultimately led to an understanding of the micro-world through the elaboration of a new theory called quantum mechanics (QM). However, it was soon realised that the total determinism of classical physics was lost. The nature of reality had changed dramatically. In the new theoretical regime, if you tell me how the world is now, QM will tell you the probability that the world is in this state or in that.  Albert Einstein. Credit: NobelPrize.org Einstein was one of the principal founders of the theory of QM, but it is well known that over time he came to reject it as a complete description of the Universe. Much has been made of Einstein’s resistance to QM, summed up by his memorable quote that “God does not play dice with the world”. However, Einstein could not deny that QM probabilities provided a spectacularly accurate prediction of what was going on in the microworld. Instead, he believed that QM was a provisional theory that would ultimately be replaced by a deeper understanding, and the new theory would eliminate the probabilistic attributes. He could not come to terms with the idea that probabilities defined the Universe, and felt there must be an underlying reality that QM did not describe. He believed that this deeper understanding would emerge from a new theory involving what has become known as ‘hidden variables’. On a personal note, I have to say I have great sympathy with Einstein’s view. As an undergraduate, with a very immature appreciation of QM, I too could never get to grips with it from the point of view of its interpretation of how the Universe works. This is one of the reasons why I studied general relativity – Einstein’s gravity theory – at doctorate level, which is inherently a classical theory.  Getting back to the discussion, Einstein strived to find his ultimate theory until the end of his life. Along the way, he was always attempting to find contradictions and weaknesses in QM. If he believed that he had found something, he would throw out a challenge to his circle of eminent ‘QM believers’. This stimulating discourse continued for many years. Then in 1935, with the publication of a paper with coauthors Podolsky and Rosen, Einstein believed he had found the ultimate weakness in QM in a property referred to as quantum entanglement (QE). This publication became known as the ‘EPR paper’. In broad terms, QE can be summarised along the lines of – if two objects interact and then separate, a subsequent measurement of one of them revealing some attribute would have an instantaneous influence on the other object regardless of their distance apart.  You might ask, why does this have such a profound impact on our understanding of reality? To grasp this, we need to discuss in a little more detail what this means when we consider quantum objects, like subatomic particles, and their quantum qualities, such a quantum spin. We have discussed the enigma of quantum spin before (see the March 2022 blog post). If we measure the quantum spin of a particle about a particular axis, then the result always reveals that it is spinning either anti-clockwise or clockwise (as seen from above), with the same magnitude. The former state is referred to ‘spin up’ and the latter ‘spin down’. There are just two outcomes, and this is a consequence of the quantised nature of the particle’s angular momentum (or rotation). As I have said before – nobody said quantum spin was an intuitive concept! It is possible to produce two particles in an interaction in the laboratory such that they zoom off in opposite directions, one in a spin up state and the other in a spin down state (for example). In the process of their interaction the two particles have become entangled, and we can measure their spin in detectors placed at each end of the laboratory. Another part of this story is understanding the nature of measurement in QM. In the example we have chosen above, the conventional interpretation of QM says that the particle’s spin state is only revealed when a measurement takes place. Prior to this moment the particle is regarded as being in a state in which it is neither spin up nor spin down, but in a fuzzy state of being both. The probability of one or other state is defined by something called the wave function, and a collapse of the wave function occurs the moment a measurement is made, to reveal the actual spin state of the particle. This process is something of a mystery, and is still not fully understood. However, that is another story. For interested readers, please Google ‘the collapse of the wave function’ for more detail. So, in our discussion, we have two ways of interpreting our experiment. That of QM which says that the spin state of the particle is only revealed when a measurement is made, and that of Einstein who believed in an underlying reality in which the spin state has a definite value throughout. If you think about the two entangled particles created in the lab, discussed above, then QE only presents us with an issue if QM is correct and Einstein is wrong. In this case, the measurement of the spin of one particle reveals its value (up or down), and an instantaneous causal influence will reveal the state of the other (the opposite value), even if the two particles are light years apart. Einstein called this "strange spooky action at a distance”, and it troubled him deeply, particularly as both his theories of relativity forbid instantaneous propagation of any physical influence. QM could not, in his view, give a full final picture of reality. For years, nobody paid much attention to the EPR paper, mostly because QM worked. The theory was successful in explaining physics experiments and in technology developments. Since no one could think of a way of testing Einstein’s speculation that one day QM would be replaced by a new theory that eliminated probability, the EPR paper was regarded merely as an interesting philosophical diversion.  John Stuart Bell. Credit: CERN Einstein died in 1955, and the debate about QE seemed to die with him. However, in 1964 an Irish physicist called John Stuart Bell proved mathematically that there was a way to test Einstein’s view that particles always have definite features, and that there is no spooky connection. Bell’s simple and remarkable incite was that doable experiments could be devised that would determine which of the two views is correct. Put another way, Bell's theorem asserts that if certain predictions of QM are correct then our world is non-local. Physicists refer to this ‘non-locality’ as meaning that there exist interactions between events that are too far apart in space and too close together in time for the events to be connected even by signals moving at the speed of light. Bell’s theorem has been in recent decades the subject of extensive analysis, discussion, and development by both physicists and philosophers of science. The relevant predictions of QM were first convincingly confirmed by the experiment of Alain Aspect (one our Nobel Prize winners) et al. in 1982, and they have been even more convincingly reconfirmed many times since. In light of these findings, the experiments thus establish that our world is non-local. I emphasise once again that this conclusion is very surprising, given that it violates the theories of relativity, as mentioned above.  The Nobel Prize winners for 2022. Credit: Optica In summary then, this year’s Nobel Prize for Physics has been awarded to Alain Aspect, John Clauser and Anton Zeilinger, whose collective works have used Bell’s theorem to establish to most people’s satisfaction (1) that Einstein’s conventional view of reality is ruled out (2) that quantum entanglement is real and (3) that quantum mechanics and quantum entanglement can be used to develop new technologies (such as quantum computing and quantum teleportation).
Usually, the Nobel Physics Prize is awarded to scientists whose work makes sense of Nature. This year’s laureates reveal that the Universe is even stranger than we thought, and in addition they achieved the rarest of things – they proved Einstein wrong! Graham Swinerd Southampton, UK November 2022  Credit: Getty Images. John writes … I am sure that many of our readers, on seeing the title of this post, will think of the use of DNA ‘fingerprinting’/ DNA profiling in police detection work. The discovery, by Alec Jeffreys and his team at Leicester University, that these profiles were unique to an individual enabled an identification of miscreants at a level of statistical certainty that had not previously been possible. Many of us remember the first conviction secured on the basis of DNA, that of Colin Pitchfork for the rape and murder of two teenage girls in Leicestershire (1). However, this was not the first time that the technique had been employed in the public arena. DNA fingerprinting had been used to establish that a young man from Nigeria was indeed the son of someone already living in the UK and could therefore stay here; the Home Office had disputed his claim and wanted to deport him. Both these examples show how the findings of science can be used in a way that promotes societal good.  Professor Sir Alec Jeffreys. Credit: The Lister Institute of Preventive Medicine One of the features of DNA profiling that often causes surprise is the small amount biological material needed in order obtain the profile. Obviously if a larger amount is available (such as from a blood sample), all well and good but if push comes to shove, the DNA from one cell is enough material to work with. This is nicely illustrated by a technique called Pre-implantation Genetic Diagnosis (PGD). As I have described elsewhere, prospective parents who are at risk of having a child with a genetic disorder may elect to undergo in vitro fertilisation (IVF) in order that the embryos may be tested for the presence or absence of the genetic mutation. In order to do this, just one cell is removed from the embryo at the eight-cell stage. This provides enough material for the genetic test.  Removing a cell from an eight-cell embryo for PGD. Credit: unknown. One of the things we hear from time to time in relation to forensic use of DNA profiling is that a case has been re-opened because of ‘new DNA evidence’. Quite often this arises because forensic scientists are becoming better and better at extracting and purifying DNA from what appear to be unpromising biological samples. But these skills also have a role in other types of investigation, of which I will give three examples. The first concerns resistance to the plague-causing bacterium, Yersinia pestis. An international group of scientists have extracted DNA from the teeth of 206 human skeletons that were buried before, during and after the 14th century plague pandemic known as The Black Death (2). The level of detailed analysis that they were able to achieve with this material is truly remarkable. They were able to show that people with a mutation in a gene that regulates part of the immune system – a mutation that makes that part of the immune system more active – were 40% more likely to survive the plague than those without the mutation. Further, that mutation is still present in the population of modern Europe and people who possess it are more likely to suffer from an over-active immune system, leading to a variety of auto-immune diseases.  Skeletons in a London plague pit. We think quite rightly that being able to analyse in detail the DNA from teeth that have been buried for 700 years is remarkable. However, the next two examples are even more amazing. A research team based at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany has extracted DNA from teeth and fragments of bone belonging to a group of eleven Neanderthals living in cave in Siberia 51,000 years ago. The team analysed DNA from the Y-chromosome, specific for males and mitochondrial genes which are passed down only via females. The analysis shows clearly the family and social structure of the little group as well as some insights into the life of this hunter-gatherer community. We do not have space to comment further on this but it is well worth reading a fuller commentary on this work, for example in New Scientist (3).  Siberian cave occupied by group of Neanderthals. Credit: Laurits Skov et al. This brings us to our third example. One of the scientists who investigated the Siberian group of Neanderthals was Professor Svante Pääbo. Earlier this year he was awarded the Nobel Prize of Physiology and Medicine (4). He is an interesting choice because, unlike many Nobel Prize winners, he is not very well known in the wider science scene, despite his huge contributions to our understanding of the evolution of early humans and other hominins. This has involved refinement and improvement of methods for extraction of ancient DNA enabling Pääbo and his team to analyse and compare DNA from bones and teeth of Neanderthals, Denisovans (see Chapter 6 of the book) and early humans and DNA from a range of modern humans. This analysis included a full sequence of the nuclear genome of Neanderthals which was a truly remarkable achievement, almost worthy of a Nobel Prize on its own! His work showed that Neanderthals and Denisovans were ‘sister-groups’ existing for a time in parallel with humans (as we show on p. 148 of the book). He has also been able to measure gene-flow between these species resulting from limited inter-breeding and the extent to which present-day humans carry Neanderthal genes (and for Melanesian humans, Denisovan genes). Svante Pääbo is certainly an amazing DNA detective and a worthy winner of the Nobel Prize.  Professor Svante Pääbo. Credit: Unknown. John Bryant
Topsham, Devon October 2022 (1) I recently had the privilege of meeting one of the detectives (now retired) who had worked on the case. (2) Evolution of immune genes is associated with the Black Death | Nature and Black Death 700 years ago affects your health now | BBC News. (3) Neanderthal family life revealed by ancient DNA from Siberian cave | New Scientist. (4) The Nobel Prize in Physiology or Medicine 2022 – Advanced information.  Artemis 1 returns to the Vertical Assembly Building. Credit: NASA Graham writes ...
In case you were wondering what happened to the Artemis 1 mission …? Hurricane Ian put paid to the launch attempts and the SLS had to ‘run’ for cover back to the Vertical Assembly Building. The date of the next launch attempt is uncertain at the time of writing, but it is hoped that it may be in November 2022. Graham Swinerd Southampton, UK October 2022  The asteroid Dimorphos just moments before impact. Graham writes ...
The DART spacecraft successfully impacted the asteroid Dimorphos in the early hours of this morning (UK time: 27 Sept), and I thought you might want to see what happened! Please click here to see a video courtesy of BBC News showing the moments just before impact. We will learn in the coming days whether the experiment was successful in changing Dimorphos's orbital speed, and consequently its orbit around Didymos. Graham Swinerd Southampton, UK September 2022  Graham writes … Alongside the impact event of the DART mission (see next blog post below), the other big happening this month is the proposed launch of the Artemis 1 mission – the first uncrewed test of the systems that are intended to return astronauts to the moon. The objectives of the Artemis programme are to establish a permanent crewed base on the moon, and to enable and test the necessary systems required for future missions beyond the moon. After the lack of ethnic diversity of the Apollo moon-walking astronauts, another unofficial aim is to take women and Black astronauts (and indeed Black women astronauts) to the lunar surface. NASA have already identified its ‘Artemis Team’ of 18 American candidates, and the involvement of other space agencies – ESA (European Space Agency), JAXA (Japan Aerospace Exploration Agency) and the CSA (Canadian Space Agency) – ensures a mix of other nationalities in future landing crews. The Artemis programme will also be supported by other initiatives, in particular the Lunar Gateway, which is a small, lunar-orbiting space station. This is expected to be in place by about 2027, and is intended to operate as a solar-powered communications node, a science laboratory and a short-term habitation module for astronauts.  Artemis 1 mission profile. Unfortunately, the efforts to launch the Artemis 1 mission have not been successful so far. The first attempt took place on 29 August, but was abandoned because the temperature of one of the four main engines was indicated to be above the maximum allowable for launch. A second attempt, too, was aborted on 3 September due to a service arm fuel supply line leak. I have to admit that I tuned in on both occasions to NASA’s excellent live stream HD TV coverage with great excitement and anticipation. At my ‘great age’, I feel very impatient to see space exploration programmes up and running again – I just want them to get on with it! The next launch opportunity is 27 September, with a back-up on 2 October, and I shall be tuning again to the live coverage.  The Orion spacecraft configuration.  The Space Launch System (SLS) Artemis 1 waits on the launch pad, prior to the recent launch attempts. The Artemis 1 mission will be the first outing of the Orion spacecraft, which is planned to be of 38 days duration. Looking at the spacecraft configuration, at first sight it looks very much like the Apollo Command and Service modules, with the obvious difference being that Orion has deployable solar arrays for power generation. The power system on Apollo used fuel cells, which are effectively chemical engines that need an input of hydrogen and oxygen to produce electricity and water. This change facilitates the need for an additional water tank to supply the crew’s needs. However, the most significant difference is that the cone-shaped Orion crew module is significantly larger than the equivalent Apollo module, with about 30% more interior volume. Consequently, Orion missions will accommodate four crew members for a typical mission duration of about 21 days. Another significant difference is that the Orion Service module is European in design and manufacture. This cylindrically-shaped module is based upon ESA’s Automated Transfer Vehicle (ATV) (1) and provides the necessary services, such as power, propulsion, communications and life support & environmental control, required to keep the crew alive and to ensure a successful mission. The Orion system’s main engine, located at the rear end of the Service module, is a souped-up version of the Space Shuttle’s orbital maneuvering system engine, with a thrust of 33 kN. Mention of this prompts memory of a very unlikely encounter a while ago with a NASA engineer who worked on the development of this Shuttle propulsion technology for the Orion spacecraft. In 2011, my wife and I had a lovely holiday break walking the coastal path of Pembrokeshire, South Wales, and on this particular day I was wearing my NASA baseball cap. Coming the other way was a couple, and the gentleman was wearing a similar cap. We started to converse, and found that we shared a professional interest in space technology. He told me about his work on the Orion programme, and I told him about the upcoming, and ground-breaking ESA comet lander mission, called Rosetta, which he’d known nothing about. A remarkable meeting, in a beautiful place in lovely weather, which would not have happened if I hadn’t been wearing my NASA cap to protect me from the sun!  The SLS - workhorse of the Artemis programme.  Anyway, back to Artemis. One thing that surprised me about the new Space Launch System (SLS) was that NASA has returned to the Saturn V philosophy used on the Apollo programme launches. This is along the lines of stacking everything– the crew and service modules, plus the lunar lander module – all on one rocket. The reason for my surprised reaction is the intention to put people on top of such a large vehicle. The energy contained within its chemical propellants is equivalent to that of a small atom bomb. Despite the existence of a dedicated launch escape system, this seems to me to be an unnecessary risk. The Agency got away with it on the 13 Saturn V launches during the Apollo era, but why take the risk now? There is in fact a better – safer and more flexible – way of doing this, which was proposed during the Constellation ‘return to the moon’ programme in around 2004. At that time, the imminent retirement of the Space Shuttle in 2011 dictated a rethink of the American space programme by the then-Bush administration. There had been a realization – a hard lesson learned – that complex spacecraft like the space shuttle are dangerous. Seven flight crew were killed on launch in the Challenger accident in 1986, and another seven died when the shuttle Columbia broke up on reentry in 2003. In light of this, a new approach to launching people was recommended in the Constellation programme. In this proposal, to launch the crewed Orion spacecraft a new man-rated launch vehicle was developed called Ares 1 using existing components derived from Shuttle and Apollo hardware. This new vehicle was small and very simple, with a genuine crew escape system, with the result that it would be very reliable and safer for future crew launches to Earth orbit and for lunar missions. The hardware for the mission, for example the lunar lander, equipment required for developing or supplying a moon base and a propulsion stage, would be launched separately on an uncrewed, heavy-lift launch vehicle, called Ares 5. Subsequently, the crewed vehicle and the mission payload vehicle would rendezvous in orbit, before departure for the moon. Although the Ares 1 and 5 launch vehicles were to be developed primarily for lunar missions, NASA envisaged a wider role for them involving crewed space missions to destinations other than the moon. A test flight of Ares 1 was performed, designated Ares 1-X, but nevertheless the Constellation programme was cancelled by the incoming Obama administration in 2010. With the retirement of the Shuttle in 2011, this left the US Space programme in the remarkable position of being principal operator of the International Space Station, but without any means for US astronauts to reach it in Earth orbit, other than by ‘hitching a ride’ on Russian crewed vehicles. For more detail about the Constellation programme, please see (2).  Moon-walking astronaut. Credit: NASA. You might ask, why am I discussing return-to-the-moon space programmes in a blog to do with science and faith? Well firstly, with my physicist’s hat on, the Artemis launch is a truly major event in the realm of the physical sciences. But then secondly, and perhaps less obviously, the spiritual or religious experiences of astronauts are worth reflecting upon. And this is not limited to moon-walking astronauts, but can be extended to those who have spent considerable time in Earth-orbiting space stations.
It is no secret that several of the Apollo astronauts were practicing Christians. Perhaps the most overt evidence of this is the remarkable occasion when the three astronauts aboard the Apollo 8 lunar-orbiting mission, Frank Borman, Jim Lovell and William Anders, read the first 10 verses of the first chapter of Genesis on Christmas Eve in 1968 (3). Then, on the occasion of the first historic landing mission Apollo 11, shortly before the lunar surface walk lunar module pilot Buzz Aldrin addressed the people of Earth: “I would like to request a few moments of silence … and to invite each person listening in, wherever and whomever they may be, to pause for a moment and contemplate the events of the past few hours, and to give thanks in his or her own way”. He then celebrated communion (the taking of bread and wine in remembrance of the sacrifice of Jesus Christ). Also, the commander of the final landing mission Apollo 17, Eugene Cernan, made no bones about his faith and was awed by what he believed was God’s amazing creation while on the lunar surface. He later commented: “There is too much purpose, too much logic [in what we see about us]. It was too beautiful to happen by accident. There has to be somebody bigger than you, and bigger than me …” (4). Other moon-walking astronauts related spiritual experiences induced by their journey to the lunar surface. Notably Apollo 14 astronaut Edgar Mitchell commented that “something happens to you out there”, and Apollo 15 astronaut Jim Irwin quoted the Bible during his lunar walk (5), and felt “touched by grace”. I guess it’s not too surprising that devout spacefarers would relate how their lunar mission influenced and strengthened their faith. Perhaps what is more remarkable is that many experienced a spiritual dimension in their lunar visit, simply by virtue of the ‘cosmic awe’ they encountered. It would seem that space in some way connects us to the divine. Graham Swinerd Southampton, UK September 2022 (1) The ATV was used for supply missions to the International Space Station up to 2015. (2) Graham Swinerd, How Spacecraft Fly: Spaceflight without Formulae, Springer, 2008, pp. 222-225. (3) Graham Swinerd & John Bryant, From the Big Bang to Biology: where is God? KDP publishing, 2020, p. 45. (4) Ibid., p 208. (5) Holy Bible (NIV) Psalm 121:1 “I lift my eyes to the mountains – where does my help come from?” Graham writes … This blog post is a very brief heads-up about the upcoming impact event, which is the centre piece of NASA’s DART (Double Asteroid Redirection Test) mission. This will occur, as planned, on 26 September. For more detail about the mission, please refer to the December 2021 blog post, which includes a video discussion between John and myself.  Long-range image of Didymos and Dimorphos acquired by DART spacecraft on 27 July 2022.  Analysis of the impact dynamics will be acquired by examination of the changes in Dimorphos's orbit. Essentially, this is the first spacecraft mission devoted to planetary defense science. In particular, the objective is to study the effectiveness of the kinetic impactor technique in changing the orbit of an asteroid to prevent a future, devastating asteroid collision with our home planet. Although such collisions with a large asteroid (greater than, say, 1 kilometre in diameter) are very rare, nevertheless we know that such events are inevitable in the long term. For this test, the target asteroid is a 160 metre diameter object called Dimorphos, which itself is in orbit around a larger asteroid (780 metres across) called Didymos. It’s worth pointing out that neither object poses an impact threat to the Earth! The idea is that the spacecraft will impact Dimorphos, causing a tiny change in its orbital speed. Although this change is very difficult to measure directly, the magnitude of the change can be calibrated very precisely by observing long-term changes in Dimorphos’s orbit around Didymos. In particular, the resulting cumulative change in its orbit period over many orbit revolutions can be observed subsequently using Earth-based telescopes. Watch out for media coverage of this historic event in the coming days, and for information about what DART tells us about planetary defense in slower time. Graham Swinerd Southampton, UK September 2022 John writes ...  Credit: John Bryant In June’s post on this blog, I wrote about the CO2 emissions arising from production of different types of food; I also looked at the amount of land needed to produce the same range of foods. The obvious conclusion to draw from these data is that, both nationally and globally, we need to reduce the consumption of meat and meat-based foods in favour of plant-based foods. A similar conclusion was made in the 2020 report published by the UK Government’s Food Adviser, Henry Dimbleby (1). I need to emphasise that neither Dimbleby nor I are saying that everyone must be vegetarian or vegan; that is a matter of personal choice (we also note that some types of land are not suitable for crop production). However, we are emphasising that for the sake of the climate (and biodiversity) and in order to feed a growing global population, total meat consumption needs to be drastically reduced and plant-based food consumption needs to be increased. From a Christian perspective we can say that this shift is an aspect of both good stewardship and care for our neighbour.  Credit: John Bryant This imperative to increase the consumption of plant-based foods also has implications for the plant science research community. Can we improve productivity, increase the efficiency of land use while at the same time reducing the need for application of fertilisers and pesticides? Understanding how plant genes work at the most fundamental level was the main area of my own research for many years. The combination of this level of research with studies of plant growth and crop yield will be vital if plant-based agriculture is to meet the challenges of the 21st century and beyond, as I recently discussed with my friend and colleague, Professor Ros Gleadow. In addition to being a Professor at Monash University, Melbourne, Ros is President of the Global Plant Council, an organisation dedicated to promotion of plant science education and research and to social and global justice in the applications of developments in the science. Earlier this summer she came to Europe to attend some conferences and meet other plant scientists. She spent two days in Exeter during which we were able to have extensive discussions about plant science research in general and our own interests in particular.  Credit: Ros Gleadow During her visit we spent a few hours in the Department of Biosciences at Exeter University, talking to some of the plant molecular biologists about their research. Amongst the several beautiful (and I use the word deliberately) projects, I want to mention just two. Firstly, many years of focussed research have revealed a network of responses at genetic level to the main stresses that climate change impose on plants, namely heat and drought. This will facilitate the breeding of crops (probably using GM and genome editing techniques) that are more resilient to climate change. Secondly, plants that apparently cope well with increased temperatures may be less able to cope with other stresses such as attacks by bacteria, fungi or viruses. It is a complex picture that will need more work to understand. More recently I have been able to continue my conversation with Ros, now back in Melbourne, courtesy of Zoom. There is a video that accompanies this blog post, which you can see by clicking here.  We talk about the work of the Global Plant Council, about the need for fairness and equality in all aspects of plant science and its applications and about priorities in plant science research. One very recent development that excites both of us is the use of GM technology to increase the efficiency of the mechanisms that plants (in this case, soya bean plants) use to capture the energy from sunlight. This led to a very marked increase in the rate of photosynthesis. It may be hard for non-biologists to appreciate how amazing this is. Because photosynthesis traps and uses energy from the sun, it is the ‘engine’ that drives all life on Earth. For an individual plant, increased rates of photosynthesis imply greater growth rates and greater productivity which is exactly what the international team of researchers found. The importance of this work was recognised by the media. In the UK, ‘serious’ newspapers (2) ran articles on it and it also featured on the BBC’s website (3). The excitement is certainly justified. If the technology can be used with other crops and especially with the major cereals, it will be a real ‘game-changer’ for global food production. As the research team leader, Professor Stephen Long, University of Illinois stated ‘This result is really relevant right now, [when] one out of 10 people on the planet are starving’. So, watch this space: we will report significant developments here. John Bryant
Topsham, Exeter August 2022 (1) In a recent interview by The Guardian newspaper, Dimbleby repeated this recommendation: ‘England must reduce meat intake to avoid climate breakdown, says food tsar’, The Guardian, 16 August 2022. (2) E.g., ‘New GM soya beans give 25% greater yield in global food security boost’, The Guardian, 18 August 2022. (3) https://www.bbc.co.uk/news/science-environment-62592286 |
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